Current Issue : January-March Volume : 2023 Issue Number : 1 Articles : 4 Articles
Objective of this research was to assess the variation in cost among different brands of anticancer drugs available in Indian pharmaceutical market. The price of different brands of the anticancer drugs available in the Indian pharmaceutical market was assessed. The drug cost was analyzed according to the availability of parenteral and oral drug formulations dosage form. The difference in the maximum and the minimum cost variation of the anticancer drugs manufactured by different pharmaceutical companies was determined; the percentage variation in price was calculated. Percentage variation in cost was analyzed for 41 different formulations of 20 anticancer drugs. Highest cost variability is seen with Estramustine 140 mg capsule (6726.3%) and the lowest with Goserelin 3.6mg injection (13.79%). 12 formulations showed more than 500% cost variation, largest with Estramustine 140mg capsule (6726.3%) followed by Decitabine 50mg injection (1706%), Hydroxyurea 500mg capsule (1700%), Bicalutamide 50mg tablet (1467.9%), Chlorambucil 2 mg tablet (1395%), Bosutinib 100 mg tablet (1,108.7%), Cabazitaxel 60/1.5 ml injection (805.6%), Cabazitaxel 60mg injection (796.5%), Melphalan 2mg tablet (769.99%), Dactinomycin 0.5mg injection (671.69%), Melphalan 5mg tablet (528.81%) and Fludarabine 10mg tablet (514.2%)....
Drug registration and approval process varies from one country to another although the objective of all regulatory authorities of the world is same. Each regulatory authority ensures that only safe, effective and quality medicines reach to the consumer. Small countries cannot bear the financial burden of setting up their own regulatory authority and hence countries of the region join hand together to establish regional regulatory authority. ASEAN is one such regional regulatory authority founded in August 1967 in Bangkok and currently has 10 member countries. The ACTD (ASEAN Common Technical Document) format needs to be followed by the manufacturer who is willing to market the product in these member countries of ASEAN. Present article will give an overview of the drug registration process in ASEAN countries....
Transfusion related reaction is an adverse event occurring in patients undergoing blood transfusion. It can cause any patients because of the nature of that substance and patient related factors. Health care team members should be aware about these reactions and thereby can reduce these situations and can be managed by using pre medications and other drugs. This study was carried out to identify the transfusion related reactions in our hospital and to analyze the severity, causality relationship, incidence and nature of these reactions. This prospective observational study was carried out among 19 participants using designed data entry form, patient interview, case sheets and laboratory investigations from January 2021 to June 2021 in Navodaya Medical College, Hospital and Research Centre, Raichur. A total of 71 patients were undergoing blood transfusion. TRRs were observed in 19 patients. So the incidence of TRRs in our study was 26.7 %. These TRRs were associated with packed cell RBC. The most commonly caused reactions were edema at the site of injection (47.3%) followed by pruritus at the site of injection (26.3%). Most of these reactions were managed by administering Inj. Dexamethasone, followed by changing the site and administration of Inj. Avil. The study concluded that the causes of these reactions were the patient related factors and the study suggested a need for proper awareness about these reactions to health care professionals. So, they will come to know about the pre medications of these reactions....
This study's goal was to examine how antiepileptic drugs are prescribed to individuals with epilepsy in a tertiary care facility. The general medicine department of the Navodaya Medical College Hospital and Research Centre in Raichur served as the site of an observational study. 50 in-patients with epilepsy who were admitted to the general medicine ward were studied for their demographic information, clinical diagnosis, epilepsy type and prescribing pattern of antiepileptic drugs. 50 prescriptions in all were examined, with more men (62%) than women (38%) involved. Patients between the ages of 20 and 40 (52%) were more likely to have epilepsy and 79% of them had GTCS, which was followed by partial seizures and other forms. Most of them (67%) received monotherapy and phenobarbitone (28%), phenytoin (16%), levetiracetam (12%), carbamazepine (8%), lorazepam (2%) and ethosuximide (1%), are the most often given AEDs. Phenobarbitone and phenytoin were the most frequently used two drug combinations and phenobarbitone, phenytoin and carbamazepine were the most frequently used three drug combinations, which were given to 33% of the patients. In our analysis, the majority of patients were males between the ages of 20 and 40 and the most often prescribed medications were traditional AEDs taken in monotherapy with phenobarbitone, phenytoin and levetiracetam....
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